Publications
Résultats et Communications Scientifiques
Liste des publications
Publications
Articles
- Proteomic assay for rapid characterisation of Staphylococcus aureus antimicrobial resistance mechanisms directly from blood cultures. Francis Deforet, Romain Carrière, Pierre L'Aour Dufour, Roxane Prat, Chloé Desbiolles, Noémie Cottin, Alicia Reuzeau, Olivier Dauwalder, Céline Dupieux-Chabert, Anne Tristan, Tiphaine Cecchini, Jérôme Lemoine, François Vandenesch. Eur J Clin Microbiol Infect Dis. 2024 May 16. PMID: 38750334 doi: 10.1007/s10096-024-04811-0.
- Complex regulation of gamma-hemolysin expression impacts S. aureus virulence. Mariane Pivard, Isabelle Caldelari, Virginie Brun, Delphine Croisier, Michel Jaquinod, Nelson Anzala, Benoît Gilquin, Chloé Teixeira, Yvonne Benito, Florence Couzon, Pascale Romby, Karen Moreau, François Vandenesch. Microbiology Spectrum 2023 Aug 17;11(4):e0107323. doi: 10.1128/spectrum.01073-23. Epub 2023
- Targeted proteomics links virulence factor expression with clinical severity in staphylococcal pneumonia. Pivard M, Bastien S, Macavei I, Mouton N, Rasigade JP, Couzon F, Youenou B, Tristan A, Carrière R, Moreau K, Lemoine J, Vandenesch F. Front Cell Infect Microbiol. 2023 Apr 3;13:1162617. doi: 10.3389/fcimb.2023.1162617. eCollection 2023. PMID: 37077532 Free PMC article.
- Scout-multiple reaction monitoring: A liquid chromatography tandem mass spectrometry approach for multi-residue pesticide analysis without time scheduling. Arnaud Salvador , Romain Carrière , Sophie Ayciriex , Christelle Margoum , Yves Leblanc et al. Journal of Chromatography A, 2020, 1621, pp.461046. ⟨10.1016/j.chroma.2020.461046⟩.
Communications
Communications Orales
2023
- Direct, Rapid and Accurate Identification of Sepsis Causative Micro-Organisms from Positive Blood Cultures Using A SCOUT-triggered MRM Proteomics Assay. Maud Gregson, Iulia Macavei, Jérôme Lemoine Mass Spectrometry & Advances in the Clinical Lab 2023, Apr 2023, Monterey (CA), United States
- A Single and Rapid Zeno SWATH DIA Proteomic Analysis for Concomitant Identification and AMR Profiling of Micro-organisms from Positive Blood Cultures. Iulia Macavei , Eva Peyrache , Maud Gregson , Romain Carrière , Roxane Prat et al. MSACL 2023 - 13th Annual Conference & Exhibits, The Association for Mass Spectrometry & Advances in the Clinical Lab, Apr 2023, Monterey (CA), United States
2022
- Fast and accurate identification and antibiotic resistance profiling of micro-organisms in blood cultures by SWATH-MS proteomics. Iulia Macavei , Eva Peyrache, Maud Gregson, Romain Carrière, Roxane Prat et al. SCIEX Breakfast Seminar, The pursuit of new biomarkers, 70th Conference on Mass Spectrometry and Allied Topics, American Society for Mass Spectrometry; SCIEX, 6th Jun 2022, Minneapolis, United States
- Fast and accurate identification and antibiotic resistance profiling of micro-organisms in blood cultures by SWATH-MS proteomics. Iulia Macavei, Eva Peyrache, Maud Gregson, Romain Carrière, Roxane Prat et al. 70th Conference on Mass Spectrometry and Allied Topics, American Society for Mass Spectrometry, 7th Jun 2022, Minneapolis (Minnesota), United States
- A single and rapid SWATH DIA proteomic analysis for concomitant identification and antibiotic resistance profiling of micro-organisms from positive blood cultures. Iulia Macavei, Eva Peyrache, Maud Gregson, Romain Carrière, Roxane Prat et al. - 62nd LBMSDG Meeting, The Francis Crick Institute, London Biological Mass Spectrometry Discussion Group; SCIEX, Dec 2022, London (UK), United Kingdom
- Direct and rapid identification of sepsis causative micro-organisms from blood cultures using SCOUT-MRM proteomics assay. Maud Gregson, Iulia Macavei, Romain Carrière, David Cox, Yves Le Blanc et al. - Keynote lecture, Analytics 2022, Sep 2022, Nantes, France Streamlining blood stream infection characterization using targeted mass spectrometry based on Scout-MRM and Zeno-PRM. Francis Deforet, Jérôme Lemoine - EuPA, Apr 2022, Leipzig, Germany
- Fast and accurate characterisation of extended-spectrum beta-lactamases (ESBL) producing Enterobacteriaceae by RPLC-MS/MS proteomics and prior-sample addition of Ion-Pairing Reagent (IPR). Eva Peyrache , Romain Carrière , F. Robin , François Vandenesch , Arnaud Salvador et al. Analytics 2022, Sep 2022, Nantes, France
2021
- Potential of high-resolution MS as an efficient tool in clinical research laboratories. Application to bacterial infections and antibiotic susceptibility testing. Francis Deforet , Jérôme Lemoine. HUPO 2021 ReCONNECT Congress, Human Proteome Organization (HUPO), Nov 2021, virtual congress, Canada
2020
- Concomitant Identification, AntiBIOtic ResIstance and Virulence evaluation of bacterial pathogens with targeted mass spectrometry. Francois Vandenesch, Jérome Lemoine. Sciex meeting. Boston, Jan 2020.
- Mass spectrometry for the diagnosis of sepsis. Francois Vandenesch, Jérome Lemoine. Worshop Mass spectrometry and imaging. Les pensières, October 14, 2020
- Microbial Diagnosis In septic patients: SOC and alternatives. Francois Vandenesch, Jérome Lemoine. Lyon Biopole conference October 16, 2020
2019
- Multiplexed detection and quantification of the protein effectors of antibiotic resistance in clinical strains of Pseudomonas aeruginosa and Enterobacteriaceae by Scout-MRM – Application to positive blood cultures. Romain Carrière, Nicolas Mouton, Iulia Macavei, Olivier Dauwalder, François Vandenesch et al. SMAP2019, Société Française de Spectrométrie de Masse (SFSM) et la Société Française d’Electrophorèse et Analyse Protéomique (SFEAP), Sep 2019, Strasbourg, France
Communications
Posters
2023
- Prediction of Pseudomonas aeruginosa antibiotic resistance levels using machine learning and protein quantification from blood cultures. Gabriel Carvalho, Romain Carriere, Roxane Prat, Chloé Desbiolles, Tiphaine Cecchini, Jérôme Lemoine, François Vandenesch, Jean Philippe Rasigade. European Congress of Clinical Microbiology and Infectious Diseases - ECCMID 33ème 15-18 avril 2023, Copenhagen Danemark
- Deciphering Pseudomonas aeruginosa AMR in clinical strains using Proteomics. P. L'aour-Dufour, I. Macavei, R. Carrière, G. Carvalho, F. Deforet, T. Cecchini, J. Lemoine, F. Vandenesch. European Congress of Clinical Microbiology and Infectious Diseases - ECCMID 33ème 15-18 avril 2023, Copenhagen Danemark
- Move aside genomics: using proteomics for rapid sepsis diagnosis. Tiphaine CECCHINI, Romain CARRIERE, Chloé DESBIOLLES, Roxane PRAT, Lilya WREYFORD, Francis DEFORET, Maud GREGSON, Pierre L'AOUR DUFOUR, Iulia MACAVEI, Eva PEYRACHE, Delphine ARQUIER, Gabriel CARVALHO, Jean-Philippe RASIGADE, Olivier DAUWALDER, Jerome LEMOINE, François VANDENESCH - European Congress of Clinical Microbiology and Infectious Diseases - ECCMID 33ème 15-18 avril 2023, Copenhagen Danemark
- Rapid identification of sepsis causative micro-organisms directly from positive blood cultures using a highly multiplexed targeted proteomics assay. M. Gregson, T. Cecchini, I. Macavei, R. Carrière, C. Desbiolles, R. Prat, L. Wreyford, F. Deforet, P. L’aour-Dufour, E. Peyrache, D. Arquier, G. Carvalho, J.P. Rasigade, O. Dauwalder, J. Lemoine, F. Vandenesch. European Congress of Clinical Microbiology and Infectious Diseases - ECCMID 33ème 15-18 avril 2023, Copenhagen Danemark
- Expression matters: contribution of a highly multiplexed proteomic method to decipher staphylococcal pathogenesis. S. BASTIEN1,, M. PIVARD, B. YOUENOU, C. BOUCHIAT I. MACAVEI, N. MOUTON, J.-P. RASIGADE, F. COUZON, A. TRISTAN, R. CARRIERE, K. MOREAU, J. LEMOINE and F. VANDENESCH, V. Gordon Research Conference on staphylococci. Waterville valley, July 30 - August 4, 2023, USA.
2022
- Rapid method for identification of methicillin-resistant Staphylococcus aureus in positive blood cultures with 100% sensitivity. Francis Deforet, Roxane Prat, Tiphaine Cecchini, Pierre l’Aour Dufour, François Vandenesch, Jérôme Lemoine .Analytics, Nantes, Septembre 2022.
- Fast and accurate identification and antibiotic resistance profiling of micro-organisms in blood cultures by SWATH DIA proteomics. Iulia Macavei, Eva Peyrache, Maud Gregson, Romain Carrière, Francis Deforet et al. Analytics 2022, Sep 2022, Nantes, France
- Direct and rapid identification of sepsis causative micro-organisms from blood cultures using SC OUT-MRM proteomics assay. Maud Gregson - ASMS 2022, Jun 2022, Minneapolis, United States
- Rapid method for identification of methicillin-resistant Staphylococcus aureus in positive blood cultures with 100% sensitivity. Francis Deforet, Roxane Prat, Tiphaine Cecchini, Pierre l’Aour Dufour, François Vandenesch, Jérôme Lemoine ASMS, Minneapolis, USA, Juin 2022.
- Ertapenem resistance in Klebsiella pneumoniae: porin quantification combined with beta-lactamase detection. Romain Carrière, Jean-Philippe Rasigade, François Vandenesch, F. Robin, J. Lemoine Analytics 2022, Sep 2022, Nantes, France.
- Corrélation expression des porines et résistance ertapénème chez K. pneumoniae par spectrométrie de masse ciblée. Romain Carrière, Jean-Philippe Rasigade, François Vandenesch, F. Robin, J. Lemoine. RICAI 2022, Dec 2022, Paris, France
- Fast and accurate characterisation of extended-spectrum beta-lactamases (ESBL) producing Enterobacteriaceae by RPLC-MS/MS proteomics and prior-sample addition of Ion-Pairing Reagent (IPR). Eva Peyrache , Romain Carrière , F. Robin , François Vandenesch , Arnaud Salvador et al. Analytics 2022, Sep 2022, Nantes, France
- Detection rapide de B-lactamases a Spectre Etendu (BLSE) par spectrométrie de masse ciblée. Tiphaine CECCHINI, Romain CARRIERE, Jérôme LEMOINE, François VANDENESCH, Olivier DAUWALDER. Ricai 2022.
- Novel blood culture medium formulation improves Candida albicans detection. P. L'aour Dufour, T. Cecchini , F. Deforet , O. Dauwalder , F. Vandenesch - ECCMID 2022 à Lisbonne 23/04/2022 – 26/04/2022
- Identification par approche combinée génomique et protéomique du mécanisme de résistance à l’amoxicilline-acide clavulanique chez Campylobacter. Francis Deforet1, Quentin Jehanne2, Lucie Bénéjat2, Roxane Prat3, Chloé Desbiolles3, Astrid Ducournau2, Richard Bonnet4, François Vandenesch3, Jérôme Lemoine1, Philippe Lehours2,5. RICAI, Paris, Décembre 2022.
Communications
Webinars & Virtual Conferences
- Contribution of a Highly Multiplexed Proteomic Method to Decipher Staphylococcal Pathogenesis. Francois Vandenesch, 2nd International Virtual Conference on Staphylococcal Infections (STAPH-2023) 27-28/02, 2023.
- A single and rapid Zeno SWATH DIA proteomic analysis for concomitant identification and antibiotic resistance profiling of micro-organisms from positive blood cultures. Iulia Macavei, Eva Peyrache, Maud Gregson, Romain Carrière, Roxane Prat et al. - Evosep Sepsis Webinar, Evosep Biosystems, Feb 2023, Online webinar, France
- Fast and accurate identification and antibiotic resistance profiling of micro-organisms in blood cultures by SWATH-MS proteomics. Iulia Macavei, Eva Peyrache, Maud Gregson, Romain Carrière, Roxane Prat et al. Advances in Proteomics & Metabolomics 2022, Technology Networks; SCIEX, Sep 2022, Online webinar, United Kingdom
Brevets
- 2022 Brevet BLSE FR2204982 Descriptif : Procédé d’identification des enzymes BLSE chez les entérobactéries. France, Patent n° : FR 2204982. 2022. Date dépôt: 24/05/2022
- 2022 Brevet SARM/pbp2A FR2200268 Descriptif : PROCEDE DE DETERMINATION DE LA RESISTANCE A LA METICILLINE DE SOUCHES DE STAPHYLOCOCCUS AUREUS. France, N° de brevet: FR-2200268. 2022 Date dépôt: 13/01/2022
- 2021 Brevet IDENTIFICATION EP 21305988.4 Descriptif : IDENTIFICATION OF MICROORGANISMS BASED ON IDENTIFICATION OF PEPTIDES USING A LIQUID SEPARATION DEVICE COUPLED WITH A MASS SPECTROMETER AND PROCESSING MEANS France, N° de brevet: EP20210305988 20210715. 2021 Date dépôt: 15/07/2021
- 2020 Brevet TREEAGE FR3106414 Descriptif : Procédé d’identification et de caractérisation d’une population microbienne par spectrométrie de masse FR2000471 Date dépôt: 17/01/2020
